shp2 -| il6rc_p
jak1 -> il6rc_p
il6rc -> il6rc_p
shp2_a -| il6rc_p
nfkb -| a2m_gfbg
stat3_ta -> a2m_gfbg
il6rc_p -> mek6
cam_ca -> camk24
stat3_ta -> cebpd
dum_il6rc_p_or_grb2_vav -> vav
socs1 -| vav
mek4 -> pkcd
akt -| bad
p38 -> cebpb
stat3_ta -> cebpb
stat3_py -> stat3_ta
dum_mtorc1_or_pkcd_stat3_ta -> stat3_ta
slim -| stat3_ta
pias3 -| stat3_ta
socs1 -| ir
socs3 -| ir
gab1_mem_p -> plcg
pi3k -> pip3
pten -| pip3
shp2 -| irs1_py
irs1_ps -| irs1_py
shp2_a -| irs1_py
ras -> raf1
pdk1 -> akt
pip3 -> akt
mtorc2 -> akt
ship -| akt
phlpp -| akt
rac1 -> mekk1
cebpb -> var_app
cebpd -> var_app
akt -| gsk3
mekk1 -> mek4
stat3_ta -> cfos
il6 -> gp80s_a
gp130s -| gp80s_a
shp2 -> tdum_shp2_il6rc_p
shp2_a -> tdum_shp2_il6rc_p
stat3_ta -> cmyc
shp2 -| stat3_py
jak1 -> stat3_py
il6rc_p -> stat3_py
cyt_ptpe -| stat3_py
shp2_a -| stat3_py
camk24 -> dum_pkcd_camk24_stat1_ta
pkcd -> dum_pkcd_camk24_stat1_ta
mek1 -> erk12
stat3_ta -> socs1
dum_gp80_a_il6rc -> il6rc
gp130m -> il6rc
socs1 -> tdum_socs1_vav
shp2 -> grb2_sos
il6rc_p -> grb2_sos
mtorc1 -> dum_mtorc1_or_pkcd_stat3_ta
pkcd -> dum_mtorc1_or_pkcd_stat3_ta
akt -| casp9
sirp1a -| shp2_a
shp2 -> shp2_a
ros -| shp2_a
gab1_mem_p -> shp2_a
p38 -> mk2
erk12 -> irs1_ps
pkcd -> irs1_ps
grb2_sos -> ras
ras_gap -| ras
cebpb -> pro_hgf
cebpd -> pro_hgf
pias1 -| stat1_ta
dum_pkcd_camk24_stat1_ta -> stat1_ta
stat1_py -> stat1_ta
slim -| stat1_ta
ca -> cam_ca
cebpb -> dum_cebp_saa
cebpd -> dum_cebp_saa
akt -| fkhr
gab1_mem_p -> ras_gap
shp2_a -| ras_gap
sirp1a -| shp2
ros -| shp2
jak1 -> shp2
il6rc_p -> shp2
socs3 -| shp2
nfkb -> saa
stat3_ta -> saa
dum_cebp_saa -> saa
ip3 -> ca
p70s6k -> pro_proliferative
erk12 -> pro_proliferative
camk24 -> pro_proliferative
cebpb -| pro_proliferative
stat3_ta -> pro_proliferative
fkhr -| pro_proliferative
shp2 -> tdum_shp2_stat3_py
shp2_a -> tdum_shp2_stat3_py
plcg -> ip3
il6rc_p -> dum_il6rc_p_or_grb2_vav
grb2_sos -> dum_il6rc_p_or_grb2_vav
cfos -> crp
nfkb -| crp
stat3_ta -> crp
ras -> pi3k
gab1_mem_p -> pi3k
shp2_a -> pi3k
jak1 -> dum_gab1_kin_or_jak1_gab1_mem_p
gab1_kin -> dum_gab1_kin_or_jak1_gab1_mem_p
mtor -> mtorc2
shp2 -| stat1_py
jak1 -> stat1_py
il6rc_p -> stat1_py
cyt_ptpe -| stat1_py
shp2_a -| stat1_py
mtor -> mtorc1
camk24 -| gp130s
mk2 -| gp130s
il6 -> gp80m_a
stat3_ta -> anti_apoptotic
gsk3 -| anti_apoptotic
bad -| anti_apoptotic
casp9 -| anti_apoptotic
raf1 -> mek1
gp80s_a -> dum_gp80_a_il6rc
gp80m_a -> dum_gp80_a_il6rc
shp2 -> tdum_shp2_stat1_py
shp2_a -> tdum_shp2_stat1_py
erk12 -> socs3
p38 -> socs3
nfkb -> socs3
stat3_ta -> socs3
erk12 -> gab1_mem
pip3 -> gab1_mem
grb2_sos -> gab1_mem
erk12 -> p70s6k
mtorc1 -> p70s6k
akt -> p70s6k
vav -> rac1
mek6 -> p38
shp2 -| jak1
shp2_a -| jak1
socs1 -| jak1
socs3 -| jak1
gab1_mem -> gab1_mem_p
dum_gab1_kin_or_jak1_gab1_mem_p -> gab1_mem_p
socs3 -> tdum_socs3_shp2
stat3_ta -> junb
$a2m_gfbg: (stat3_ta & !nfkb)
$akt: ((pdk1 & (pip3 & mtorc2)) & !(phlpp | ship))
$anti_apoptotic: (stat3_ta & !((gsk3 | casp9) | bad))
$bad: (!akt | !akt)
$ca: ip3
$cam_ca: ca
$camk24: cam_ca
$casp9: (!akt | !akt)
$cebpb: (stat3_ta | p38)
$cebpd: stat3_ta
$cfos: stat3_ta
$cmyc: stat3_ta
$crp: ((cfos & stat3_ta) & !nfkb)
$dum_cebp_saa: (cebpd | cebpb)
$dum_gab1_kin_or_jak1_gab1_mem_p: (jak1 | gab1_kin)
$dum_gp80_a_il6rc: (gp80m_a | gp80s_a)
$dum_il6rc_p_or_grb2_vav: (grb2_sos | il6rc_p)
$dum_mtorc1_or_pkcd_stat3_ta: (mtorc1 | pkcd)
$dum_pkcd_camk24_stat1_ta: (pkcd | camk24)
$erk12: mek1
$fkhr: (!akt | !akt)
$gab1_mem: (grb2_sos | (erk12 & pip3))
$gab1_mem_p: (gab1_mem & dum_gab1_kin_or_jak1_gab1_mem_p)
$gp130s: (!(camk24 | mk2) | !(camk24 | mk2))
$gp80m_a: il6
$gp80s_a: (il6 & !gp130s)
$grb2_sos: (il6rc_p | shp2)
$gsk3: (!akt | !akt)
$il6rc: (gp130m & dum_gp80_a_il6rc)
$il6rc_p: ((il6rc & jak1) & !(shp2 | shp2_a))
$ip3: plcg
$ir: (!(socs1 | socs3) | !(socs1 | socs3))
$irs1_ps: (erk12 | pkcd)
$irs1_py: (!((shp2_a | irs1_ps) | shp2) | !((shp2 | irs1_ps) | shp2_a))
$jak1: (!(((shp2 | shp2_a) | socs1) | socs3) | !(((shp2 | shp2_a) | socs1) | socs3))
$junb: stat3_ta
$mek1: raf1
$mek4: mekk1
$mek6: il6rc_p
$mekk1: rac1
$mk2: p38
$mtorc1: mtor
$mtorc2: mtor
$p38: mek6
$p70s6k: ((erk12 | mtorc1) | akt)
$pi3k: (ras | (gab1_mem_p & !shp2_a))
$pip3: (pi3k & !pten)
$pkcd: mek4
$plcg: gab1_mem_p
$pro_hgf: (cebpb | cebpd)
$pro_proliferative: ((((p70s6k | camk24) | stat3_ta) | erk12) | !(((((p70s6k | erk12) | camk24) | cebpb) | stat3_ta) | fkhr))
$rac1: vav
$raf1: ras
$ras: (grb2_sos & !ras_gap)
$ras_gap: (gab1_mem_p & !shp2_a)
$saa: (dum_cebp_saa & (nfkb & stat3_ta))
$shp2: ((il6rc_p & jak1) & !((ros | sirp1a) | socs3))
$shp2_a: ((gab1_mem_p & shp2) & !(ros | sirp1a))
$socs1: stat3_ta
$socs3: (((nfkb | p38) | erk12) | stat3_ta)
$stat1_py: ((il6rc_p & jak1) & !((cyt_ptpe | shp2_a) | shp2))
$stat1_ta: ((dum_pkcd_camk24_stat1_ta & stat1_py) & !(slim | pias1))
$stat3_py: ((il6rc_p & jak1) & !((cyt_ptpe | shp2_a) | shp2))
$stat3_ta: ((dum_mtorc1_or_pkcd_stat3_ta & stat3_py) & !(slim | pias3))
$tdum_shp2_il6rc_p: (shp2 | shp2_a)
$tdum_shp2_stat1_py: (shp2 | shp2_a)
$tdum_shp2_stat3_py: (shp2_a | shp2)
$tdum_socs1_vav: socs1
$tdum_socs3_shp2: socs3
$var_app: (cebpb | cebpd)
$vav: (dum_il6rc_p_or_grb2_vav & !socs1)